Articles - Obesity

To explore the link between obesity and sexual desire, to assess how changes in body weight affect sexual desire, and to examine the role of testosterone in these changes in obese and overweight men.

In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories to 2050.

Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches to health care and policy. This Commission sought to define clinical obesity as a condition of illness that, akin to the notion of chronic disease in other medical specialties, directly results from the effect of excess adiposity on the function of organs and tissues.

The research investigates the effects of weight loss and weight cycling on metabolic outcomes, highlighting the significant influence of genetic diversity. C57BL/6 J mice showed a return to baseline metabolic conditions after weight loss, while genetically diverse DOz mice exhibited persistent metabolic issues and greater variability. The study concludes that weight cycling is detrimental, leading to hyperinsulinemia and elevated insulin secretion, with no lasting benefits from prior weight loss.

Obstructive sleep apnea is characterized by disordered breathing during sleep and is associated with major cardiovascular complications; excess adiposity is an etiologic risk factor. Tirzepatide may be a potential treatment.

In this review, we focus on the latest situation in the Asia-Pacific region, and review the diagnostic criteria of obesity, management strategies and access to treatment in the region.

The research paper addresses childhood obesity as a significant global health issue influenced by genetic and environmental factors, emphasizing the need for tailored management strategies distinct from adult obesity treatments. It reviews genetic factors, pharmacotherapy, and dietary interventions, assessing their efficacy and safety while suggesting future research directions to develop more effective, personalized healthcare solutions for this condition.

This review highlights precision nutrition (PN) as an effective strategy for managing obesity by integrating gene-nutrient interactions, intestinal microbiota, and lifestyle factors. It emphasizes PN's role in improving dietary quality and physical activity adherence, while also offering potential for long-term prevention of obesity and its related complications.

To identify perceptions and attitudes among people with obesity (PwO) and healthcare professionals (HCPs) toward obesity and its management in nine Asia-Pacific (APAC) countries, a cross-sectional online survey was conducted among adult PwO with self-reported body mass index of ≥25 kg/m2 (≥27 kg/m2, Singapore), and HCPs involved in direct patient care.

This review explores personalized prevention and management of obesity through a nutrigenetics lens, highlighting how genetic variations influence responses to different macronutrients. It identifies potential targets for obesity management, including pathways related to circadian rhythm and cholesterol metabolism, and suggests the repurposing of the SYK inhibitor fostamatinib for treatment based on genetic profiles. The study also emphasizes the importance of understanding genetic factors in lifestyle changes for effective weight management.

This study evaluates the association of 102 genetic variants with body mass index (BMI) and weight loss treatment response in a multi-ethnic population. It identifies specific single nucleotide polymorphisms (SNPs) linked to increased BMI and varying efficacy of weight loss interventions, suggesting the potential for personalized weight management strategies based on genetic profiles.

The study aimed to determine if remission of type 2 diabetes (T2D) could be achieved through a low-energy total diet replacement in an Australian primary care setting. At 12 months, 56% of participants achieved T2D remission, with an average weight loss of 8.1%.

This review highlights the effectiveness of precision nutrition in improving risk factors for obesity and type 2 diabetes by tailoring dietary recommendations to individual characteristics such as genetics and lifestyle. It suggests that this personalized approach may be a more effective strategy than conventional dietary interventions, which have shown inconsistent results.

The Korean Society for the Study of Obesity defined overweight as a BMI ≥23 kg/m2 and obesity as a BMI ≥25 kg/m2, based on a significant increase in obesity-related diseases. A waist circumference of ≥90 cm in men and ≥85 cm in women are defined as abdominal obesity, which is also correlated with obesity-related diseases.

Our study aimed to investigate people's motivations for participating in weight loss trials and determine any relationship with gender.

The study investigates motivations for participating in weight loss clinical trials, highlighting gender differences in these motivations. Improved health is a common motivation for all participants, but males are more influenced by healthcare advice, while females are driven by family and aesthetic expectations. Understanding these differences aims to enhance recruitment strategies for male participants in future trials.

In recent years, endoscopic bariatric therapies have evolved as an effective, minimally invasive and durable therapeutic option for obesity. Metabolic–bariatric surgery remains the most effective and durable treatment for patients with severe obesity, with an average weight loss of 25%–30% after one year.

With the prevalence of obesity rising unabated, particularly in developing economies, the World Obesity Federation has projected that one billion people globally, including one in five women and one in seven men, will be living with obesity by 2030.

The purpose of this review is to provide an overview of the different types of omics data: genomics, epigenomics, transcriptomics, proteomics, metabolomics and illustrate how a multi-omics approach can be fundamental for the implementation of precision obesity management.

The research paper discusses the multifactorial nature of obesity and the limitations of traditional lifestyle interventions. It aims to illustrate how a multi-omics approach, encompassing various types of omics data, can facilitate precision obesity management by identifying specific biomarkers and guiding individualized treatment plans. This integration is proposed to shift the focus from a one-size-fits-all strategy to tailored prevention and treatment of obesity and its related diseases.

In Asia, diabetes-associated death due to cardiorenal diseases were 2–3 times higher in women than men which might be due to gender disparity in quality of care and health habits.

Our group of obesity specialists from Bangladesh, Brunei Darussalam, India, Indonesia, Malaysia, Philippines, Singapore, Sri Lanka, Thailand, and Viet Nam undertook to develop consensus recommendations for management and care of adults and children with obesity in South and Southeast Asia.

The ongoing obesity epidemic represents a global public health crisis that contributes to poor health outcomes, reduced quality of life, and >2.8 million deaths each year.

Recent guidelines for managing type 2 diabetes mellitus (T2D) emphasize a personalized approach over rigid treatment algorithms, aiming to enhance patient satisfaction, medication adherence, and overall health outcomes. This strategy involves tailoring treatment goals based on individual medical and patient factors, ultimately reducing costs and complications associated with diabetes management.

The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes.

Obesity and overweight are independent risk factors of erectile dysfunction (ED). It is controversial whether weight loss can improves erectile function. We thereby performed this meta-analysis to clarify the therapeutic effect of weight loss on erectile function in overweight or obese men.

This study estimates the prevalence of central obesity in South Asian adults and examines gender differences in central obesity across cardiometabolic determinants.