The metabolic consequences of ‘yo-yo’ dieting are markedly influenced by genetic diversity
The research investigates the effects of weight loss and weight cycling on metabolic outcomes, highlighting the significant influence of genetic diversity. C57BL/6 J mice showed a return to baseline metabolic conditions after weight loss, while genetically diverse DOz mice exhibited persistent metabolic issues and greater variability. The study concludes that weight cycling is detrimental, leading to hyperinsulinemia and elevated insulin secretion, with no lasting benefits from prior weight loss.
Genetics, pharmacotherapy, and dietary interventions in childhood obesity
The research paper addresses childhood obesity as a significant global health issue influenced by genetic and environmental factors, emphasizing the need for tailored management strategies distinct from adult obesity treatments. It reviews genetic factors, pharmacotherapy, and dietary interventions, assessing their efficacy and safety while suggesting future research directions to develop more effective, personalized healthcare solutions for this condition.
Precision Nutrition Unveiled: Gene–Nutrient Interactions, Microbiota Dynamics, and Lifestyle Factors in Obesity Management
This review highlights precision nutrition (PN) as an effective strategy for managing obesity by integrating gene-nutrient interactions, intestinal microbiota, and lifestyle factors. It emphasizes PN's role in improving dietary quality and physical activity adherence, while also offering potential for long-term prevention of obesity and its related complications.
A genomics perspective of personalized prevention and management of obesity
This review explores personalized prevention and management of obesity through a nutrigenetics lens, highlighting how genetic variations influence responses to different macronutrients. It identifies potential targets for obesity management, including pathways related to circadian rhythm and cholesterol metabolism, and suggests the repurposing of the SYK inhibitor fostamatinib for treatment based on genetic profiles. The study also emphasizes the importance of understanding genetic factors in lifestyle changes for effective weight management.
Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss
This study evaluates the association of 102 genetic variants with body mass index (BMI) and weight loss treatment response in a multi-ethnic population. It identifies specific single nucleotide polymorphisms (SNPs) linked to increased BMI and varying efficacy of weight loss interventions, suggesting the potential for personalized weight management strategies based on genetic profiles.
Intensive Lifestyle Intervention for Remission of Early Type 2 Diabetes in Primary Care in Australia: DiRECT-Aus
The study aimed to determine if remission of type 2 diabetes (T2D) could be achieved through a low-energy total diet replacement in an Australian primary care setting. At 12 months, 56% of participants achieved T2D remission, with an average weight loss of 8.1%.
Precision Nutrition to Improve Risk Factors of Obesity and Type 2 Diabetes
This review highlights the effectiveness of precision nutrition in improving risk factors for obesity and type 2 diabetes by tailoring dietary recommendations to individual characteristics such as genetics and lifestyle. It suggests that this personalized approach may be a more effective strategy than conventional dietary interventions, which have shown inconsistent results.
Motivations for participation in weight loss clinical trials
The study investigates motivations for participating in weight loss clinical trials, highlighting gender differences in these motivations. Improved health is a common motivation for all participants, but males are more influenced by healthcare advice, while females are driven by family and aesthetic expectations. Understanding these differences aims to enhance recruitment strategies for male participants in future trials.
Multi-omics approaches for precision obesity management
The research paper discusses the multifactorial nature of obesity and the limitations of traditional lifestyle interventions. It aims to illustrate how a multi-omics approach, encompassing various types of omics data, can facilitate precision obesity management by identifying specific biomarkers and guiding individualized treatment plans. This integration is proposed to shift the focus from a one-size-fits-all strategy to tailored prevention and treatment of obesity and its related diseases.
Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations
Recent guidelines for managing type 2 diabetes mellitus (T2D) emphasize a personalized approach over rigid treatment algorithms, aiming to enhance patient satisfaction, medication adherence, and overall health outcomes. This strategy involves tailoring treatment goals based on individual medical and patient factors, ultimately reducing costs and complications associated with diabetes management.