In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories to 2050.
Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches to health care and policy. This Commission sought to define clinical obesity as a condition of illness that, akin to the notion of chronic disease in other medical specialties, directly results from the effect of excess adiposity on the function of organs and tissues.
Definition and diagnostic criteria of clinical obesity Read More »
The research investigates the effects of weight loss and weight cycling on metabolic outcomes, highlighting the significant influence of genetic diversity. C57BL/6 J mice showed a return to baseline metabolic conditions after weight loss, while genetically diverse DOz mice exhibited persistent metabolic issues and greater variability. The study concludes that weight cycling is detrimental, leading to hyperinsulinemia and elevated insulin secretion, with no lasting benefits from prior weight loss.
This research paper discusses the use of network modeling methods to study metabolic diseases, specifically inborn errors of metabolism, diabetes, and metabolism-related inflammation and autoimmune disorders. The main focus is on identifying causal agents and understanding the multifactorial mechanisms underlying these diseases. The paper also highlights the role of the gut microbiome in metabolic diseases, particularly in diabetes. However, there are limitations and gaps in current research that require further attention.
Network modeling approaches for metabolic diseases and diabetes Read More »
Obstructive sleep apnea is characterized by disordered breathing during sleep and is associated with major cardiovascular complications; excess adiposity is an etiologic risk factor. Tirzepatide may be a potential treatment.
Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity Read More »
This study found a U-shaped relationship between HDL and HbA1c levels in T2DM patients, with an inflection point at 59 mg/dl. Males with higher HDL are more likely to achieve glycemic control, while females show a U-shaped relationship. Further research is needed to understand this gender-specific correlation.
In this review, we focus on the latest situation in the Asia-Pacific region, and review the diagnostic criteria of obesity, management strategies and access to treatment in the region.
Obesity in the Asia-Pacific Region: Current Perspectives Read More »
The research paper addresses childhood obesity as a significant global health issue influenced by genetic and environmental factors, emphasizing the need for tailored management strategies distinct from adult obesity treatments. It reviews genetic factors, pharmacotherapy, and dietary interventions, assessing their efficacy and safety while suggesting future research directions to develop more effective, personalized healthcare solutions for this condition.
Genetics, pharmacotherapy, and dietary interventions in childhood obesity Read More »
This study found a strong correlation between platelet metrics and cardiovascular risk in prediabetic patients with coronary artery disease. Platelet indices can effectively predict the risk of CAD and can aid in early intervention planning for this high-risk group.
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