Article
A Concerted Vision to Advance the Knowledge of Diabetes Mellitus Related to Immune Checkpoint Inhibitors
This research paper discusses the growing prevalence of immune-related diabetes mellitus (irDM) caused by immune checkpoint inhibitors (ICPis). It proposes a two-pronged approach to advance knowledge and understanding of irDM, focusing on both the scientific and patient-centered aspects. The paper suggests a multidisciplinary effort to improve characterization, standardization, and treatment of irDM.
Multi-omics approaches for precision obesity management
The research paper discusses the multifactorial nature of obesity and the limitations of traditional lifestyle interventions. It aims to illustrate how a multi-omics approach, encompassing various types of omics data, can facilitate precision obesity management by identifying specific biomarkers and guiding individualized treatment plans. This integration is proposed to shift the focus from a one-size-fits-all strategy to tailored prevention and treatment of obesity and its related diseases.
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Changes in hyperglycaemia-related testing for prediabetes and type 2 diabetes mellitus management: a prospective, cross-sectional survey of 16 years of general practice data from Australia
This study examined 16 years of hyperglycaemia-related testing in Australia and found that the proportion of encounters for prediabetes and type 2 diabetes management has increased over time. GPs were influenced by changes in national insurance and clinical guidelines, but there was also evidence of “unendorsed” testing. This has significant resource implications and calls for an economic analysis to lower the risk threshold for prediabetes screening. Ongoing data is needed to inform clinical practice and policy in Australia.
Type 2 diabetes
Type 2 diabetes, which constitutes nearly 90% of the 537 million diabetes cases globally, is rapidly increasing, particularly among children and young adults. The research emphasizes the importance of early detection and management to prevent complications, highlights the potential of precision medicine and novel therapies, and discusses the barriers to effectively addressing the diabetes epidemic.
Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis
Subcutaneous semaglutide is effective for weight loss in individuals with obesity without diabetes, achieving an average reduction of 11.85% from baseline compared to placebo. However, the treatment is associated with a higher risk of gastrointestinal adverse events, treatment discontinuation, and serious adverse event
Trends in the Prevalence of Cardiometabolic Multimorbidity in the United States, 1999–2018
The prevalence of cardiometabolic multimorbidity (co-existence of ≥1 cardiometabolic diseases) in the U.S. has been increasing significantly from 1999 to 2018, with a prevalence of 14.4% in 2017-2018. This trend was observed in both genders, most age groups, and non-Hispanic White people. The most common patterns were hypertension and diabetes, hypertension, diabetes, and CHD, and hypertension and CHD. This highlights the growing concern of cardiometabolic multimorbidity as a public health issue in the U.S.
Personalized Type 2 Diabetes Management: An Update on Recent Advances and Recommendations
Recent guidelines for managing type 2 diabetes mellitus (T2D) emphasize a personalized approach over rigid treatment algorithms, aiming to enhance patient satisfaction, medication adherence, and overall health outcomes. This strategy involves tailoring treatment goals based on individual medical and patient factors, ultimately reducing costs and complications associated with diabetes management.