This research paper explores the relationship between COVID-19 and diabetes mellitus, highlighting the need for further investigation into the long-term effects of the virus on glucose tolerance and insulin sensitivity. The authors suggest regular screening for diabetes in high-risk populations with a history of COVID-19 infection and potential therapeutic interventions to prevent new-onset diabetes.
This article reviews available evidence regarding hypertension management in the Asia-Pacific region, focussing on five research questions that deal with specific aspects: blood pressure (BP) control, guideline recommendations, role of renin–angiotensin–aldosterone system (RAAS) inhibitors in clinical practice, pharmacological management and real-world adherence to guideline recommendations.
Management of Hypertension in the Asia-Pacific Region: A Structured Review Read More »
To identify perceptions and attitudes among people with obesity (PwO) and healthcare professionals (HCPs) toward obesity and its management in nine Asia-Pacific (APAC) countries, a cross-sectional online survey was conducted among adult PwO with self-reported body mass index of ≥25 kg/m2 (≥27 kg/m2, Singapore), and HCPs involved in direct patient care.
In this review, we present the efficacy and safety data for the pipeline of obesity pharmacotherapies with a focus on entero-pancreatic hormone-based treatments and we consider the clinical implications and challenges that the new era in obesity management may bring.
What is the pipeline for future medications for obesity? Read More »
This review explores personalized prevention and management of obesity through a nutrigenetics lens, highlighting how genetic variations influence responses to different macronutrients. It identifies potential targets for obesity management, including pathways related to circadian rhythm and cholesterol metabolism, and suggests the repurposing of the SYK inhibitor fostamatinib for treatment based on genetic profiles. The study also emphasizes the importance of understanding genetic factors in lifestyle changes for effective weight management.
A genomics perspective of personalized prevention and management of obesity Read More »
This study evaluates the association of 102 genetic variants with body mass index (BMI) and weight loss treatment response in a multi-ethnic population. It identifies specific single nucleotide polymorphisms (SNPs) linked to increased BMI and varying efficacy of weight loss interventions, suggesting the potential for personalized weight management strategies based on genetic profiles.
The study aimed to determine if remission of type 2 diabetes (T2D) could be achieved through a low-energy total diet replacement in an Australian primary care setting. At 12 months, 56% of participants achieved T2D remission, with an average weight loss of 8.1%.
Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes, leading to disabilities, reduced quality of life, and high costs. The pathophysiology of DFUs involves metabolic dysfunction, diabetic immunopathy, diabetic neuropathy, and angiopathy, which can lead to infections and other complications. Understanding and addressing these factors can help prevent and manage DFUs more effectively.
The pathophysiology of diabetic foot: a narrative review Read More »
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