Obesity

The research investigates the effects of weight loss and weight cycling on metabolic outcomes, highlighting the significant influence of genetic diversity. C57BL/6 J mice showed a return to baseline metabolic conditions after weight loss, while genetically diverse DOz mice exhibited persistent metabolic issues and greater variability. The study concludes that weight cycling is detrimental, leading to hyperinsulinemia and elevated insulin secretion, with no lasting benefits from prior weight loss.

Obstructive sleep apnea is characterized by disordered breathing during sleep and is associated with major cardiovascular complications; excess adiposity is an etiologic risk factor. Tirzepatide may be a potential treatment.

In this review, we focus on the latest situation in the Asia-Pacific region, and review the diagnostic criteria of obesity, management strategies and access to treatment in the region.

The research paper addresses childhood obesity as a significant global health issue influenced by genetic and environmental factors, emphasizing the need for tailored management strategies distinct from adult obesity treatments. It reviews genetic factors, pharmacotherapy, and dietary interventions, assessing their efficacy and safety while suggesting future research directions to develop more effective, personalized healthcare solutions for this condition.

This review highlights precision nutrition (PN) as an effective strategy for managing obesity by integrating gene-nutrient interactions, intestinal microbiota, and lifestyle factors. It emphasizes PN’s role in improving dietary quality and physical activity adherence, while also offering potential for long-term prevention of obesity and its related complications.

To identify perceptions and attitudes among people with obesity (PwO) and healthcare professionals (HCPs) toward obesity and its management in nine Asia-Pacific (APAC) countries, a cross-sectional online survey was conducted among adult PwO with self-reported body mass index of ≥25 kg/m2 (≥27 kg/m2, Singapore), and HCPs involved in direct patient care.

In this review, we present the efficacy and safety data for the pipeline of obesity pharmacotherapies with a focus on entero-pancreatic hormone-based treatments and we consider the clinical implications and challenges that the new era in obesity management may bring.

This review explores personalized prevention and management of obesity through a nutrigenetics lens, highlighting how genetic variations influence responses to different macronutrients. It identifies potential targets for obesity management, including pathways related to circadian rhythm and cholesterol metabolism, and suggests the repurposing of the SYK inhibitor fostamatinib for treatment based on genetic profiles. The study also emphasizes the importance of understanding genetic factors in lifestyle changes for effective weight management.

This study evaluates the association of 102 genetic variants with body mass index (BMI) and weight loss treatment response in a multi-ethnic population. It identifies specific single nucleotide polymorphisms (SNPs) linked to increased BMI and varying efficacy of weight loss interventions, suggesting the potential for personalized weight management strategies based on genetic profiles.

The study aimed to determine if remission of type 2 diabetes (T2D) could be achieved through a low-energy total diet replacement in an Australian primary care setting. At 12 months, 56% of participants achieved T2D remission, with an average weight loss of 8.1%.